Type 2 diabetes is intricately linked to an elevated risk of cardiovascular disease, heart failure, chronic kidney disease, fatty liver disease, and eye and foot complications. Conversely, these conditions heighten the susceptibility to developing type 2 diabetes. This interconnected web suggests that these health issues, including diabetes, stem primarily from the inefficient sequestering of excess energy, resulting in the accumulation of unhealthy fat (adiposopathy). Rather than viewing type 2 diabetes as a standalone condition, it is better understood as a symptom of a chronic disease complex. The conditions comprising what is termed CARAMEL disease—Cardiac, Renal, Adipo-Metabolic, Eye, and Liver disease—coexist in most individuals with type 2 diabetes.